Inhibition of Proliferation of Human Melanocytes by a KIT Antisense Oligodeoxynucleotide: Implications for Human Piebaldism and Mouse Dominant White Spotting (W)
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چکیده
منابع مشابه
Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism.
Piebaldism is an autosomal dominant genetic disorder characterized by cogenital patches of skin and hair from which melanocytes are completely absent. A similar disorder of mouse, dominant white spotting (W), results from mutations of the c-Kit protooncogene, which encodes and receptor for mast/stem cell growth factor. We identified a KIT gene mutation in a proband with classic autosomal domina...
متن کاملThe dominant white spotting oncogene allele Kit(W-42J) exacerbates XY(DOM) sex reversal.
The Y chromosome from certain populations of M. m. domesticus is incapable of normal testis determination in the B6 inbred strain resulting in XY hermaphrodites or XY females (XY(DOM) sex reversal). B6 consomic strains have been developed with either transient (B6-Y(AKR)) or severe (B6-Y(TIR)) XY(DOM) sex reversal. We report that a point mutation, the dominant white spotting oncogene allele, Ki...
متن کاملLack of apparent hematologic abnormalities in human patients with c-kit (stem cell factor receptor) gene mutations.
Considerable attention has recently been paid to the molecular biology, cell biology, and mutations of the mouse Steel (SI) and dominant white spotting (W; c-kit) loci, which respectively encode stem cell (SCF; also referred to as mast cell growth and kit ligand7-9) and its cognate cellular receptor tyrosine kinase.’O Mice with mutations at either of these loci have similar developmental defect...
متن کاملDISCOVERY OF THE DOMINANT WHITE SPOTTING (W) LOCUS AND ITS RELATIONSHIP TO THE c-kit TYROSINE KINASE RECEPTOR
HEMATOPOIESIS IS A life-long process responsible for replenishing both hematopoietic progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting stem cells.1 The daily turnover in a normal adult of approximately 1012 blood cells is tightly regulated, involving, in part, a complex interaction between soluble and membranebound stimulatory and inhibitory cytokines ...
متن کاملGenetic analysis of the dominant white-spotting (W) region on mouse chromosome 5: identification of cloned DNA markers near W.
We have assigned several mouse cDNA and genomic clones to the W region of mouse chromosome 5, established their position with respect to various marker loci in the region, and provided molecular verification that the W19H mutation is a deletion. Meiotic recombination analysis of an interspecific mouse backcross indicated the following gene order and distances [in centimorgans (cM)]: centromere-...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1994
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12392551